DETERMINATION OF MATRIX FIXED CHARGE DENSITY BY MAGNETIC RESONANCE MICROSCOPY OF BIOREACTOR-DERIVEDHYALINE CARTILAGE CORRELATES WITH BIOCHEMICAL AND BIOMECHANICAL PROPERTIES*Equilibrium Modulus (MPa)Cross-sectional Area (mm2)S-GAG/Dry Wt (%)
نویسندگان
چکیده
HYALINE CARTILAGE CORRELATES WITH BIOCHEMICAL AND BIOMECHANICAL PROPERTIES *Walter E Horton, Jr., **Chih-Tung Chen, ***Kenneth W Fishbein, **Peter A Torzilli, +***Richard GS Spencer Northeastern Ohio Universities College of Medicine, Rootstown, OH **Laboratory for Soft Tissue Research, The Hospital for Special Surgery, New York, NY ***NMR Unit, National Institute on Aging, National Institute of Health, Bethesda, MD
منابع مشابه
Biomechanical, biochemical, and histological characterization of canine lumbar facet joint cartilage.
OBJECT Tissue engineering appears to be a promising strategy for articular cartilage regeneration as a treatment for facet joint arthritis. Prior to the commencement of tissue engineering approaches, design criteria must be established to determine the required functional properties of the replacement tissue. As characterization of the functional properties of facet joint cartilage has not been...
متن کاملBiochemical markers of the mechanical quality of engineered hyaline cartilage.
The aim of this study was to determine whether or not biochemical markers can be used as surrogate measures for the mechanical quality of tissue engineered cartilage. The biochemical composition of tissue engineered cartilage constructs were altered by varying either (i) the initial cell seeding density of the scaffold (seeding density protocol) or (ii) the length of time the engineered tissue ...
متن کاملContrast enhanced computed tomography can predict the glycosaminoglycan content and biomechanical properties of articular cartilage.
OBJECTIVE An early hallmark of osteoarthritis (OA) is the progressive loss of glycosaminoglycans (GAGs), the extracellular matrix (ECM) component of articular cartilage that confers it with compressive stiffness. Our aim in this work is to establish the feasibility of using Contrast Enhanced Computed Tomography (CECT) with an anionic iodinated contrast agent - Cysto Conray II - as a minimally i...
متن کاملInjurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.
A bovine cartilage explant system was used to evaluate the effects of injurious compression on chondrocyte apoptosis and matrix biochemical and biomechanical properties within intact cartilage. Disks of newborn bovine articular cartilage were compressed in vitro to various peak stress levels and chondrocyte apoptotic cell death, tissue biomechanical properties, tissue swelling, glycosaminoglyca...
متن کاملCartilage Nominal Strain Correlates with Gag Content and Shear Modulus in Meniscectomized Joints
* **Song, Y, **Greve, J, **Gold, GE, * **Carter, DR, * **Giori, NJ * Bone and Joint Center, VA Palo Alto Health Care System, Palo Alto, CA [email protected] INTRODUCTION Meniscectomy leads to osteoarthritis (OA) in both human and animal knee joints. Spatial changes in biochemical composition and biomechanical properties over the entire surface of articular cartilage following meniscectomy h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2002